Natural Liver Detox (CRO)

There are 674 studies on elderberry and counting.

1. Hawkins, J., Baker, C., Cherry, L., & Dunne, E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary Therapies in Medicine. 2019

There are 24,245 studies on zinc and counting.

1. Zhong, W., Wei, X., Hao, L., Lin, T. D., Yue, R., Sun, X., ... & Zhou, Z. Zinc deficiency activates S1P3 -mediated hepatic stellate cell activation via the S1P3 /S1P lyase/SREBP1 positive feedback loop. Hepatology. 2020
2. Barbara M, Mindikoglu AL. The role of zinc in the prevention and treatment of nonalcoholic fatty liver disease. Metabol Open. 2021
3. Grüngreiff, K., & Reinhold, D. Zinc and the liver. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals (pp. 523-529). Academic Press. 2018

There are 5,930 studies on grape seed and counting.

1. Bak, M. J., et al. Grape seed proanthocyanidin extract ameliorates nonalcoholic fatty liver disease through regulation of lipid metabolism, oxidative stress and inflammatory cytokines. Journal of Functional Foods. 2016
2. Nassiri‐Asl, M., & Hosseinzadeh, H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive constituents: an update. Phytotherapy Research. 2016
3. Khoo, H. E., et al. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & Nutrition Research. 2017

There are 4,221 studies on beet root and counting.

1. Vulić, J. J., Čanadanović-Brunet, J. M., Ćetković, G. S., Tumbas, V. T., Djilas, S. M., Četojević-Simin, D. D., & Čanadanović, V. M. Antioxidant and cell growth activities of beet root pomace extracts. Journal of Functional Foods. 2012
2. Clifford, T., Howatson, G., West, D. J., & Stevenson, E. J. The potential benefits of red beetroot supplementation in health and disease. Nutrients. 2015
3. Ninfali, P., & Angelino, D. Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia. 2013

There are 6,840 studies on milk thistle seed extract and counting.

1. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010
2. Surai PF. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants (Basel). 2015
3. Ferenci P. Silymarin in the treatment of liver diseases: What is the clinical evidence? Clin Liver Dis (Hoboken). 2016

There are 4,353 studies on blueberry and counting.

1. Travica, N., et al. The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials. Brain, Behavior, and Immunity. 2020
2. Norberto, S., et al. Blueberry anthocyanins in health promotion: A metabolic overview. Journal of Functional Foods. 2013

There are 48,792 studies on glutathione and counting.

1. Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., ... & Nakajima, A. Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology. 2017
2. Sacco, R., Eggenhoffner, R., & Giacomelli, L. Glutathione in the treatment of liver diseases: insights from clinical practice. Minerva gastroenterologica e dietologica. 2016

There are 548 studies on TUDCA and counting.

1. Elia, A. E., Lalli, S., Monsurrò, M. R., Sagnelli, A., Taiello, A. C., Reggiori, B., ... & Albanese, A. Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis. European journal of neurology. 2016
2. Mueller, M., Castro, R. E., Thorell, A., Marschall, H. U., Auer, N., Herac, M., ... & Trauner, M. Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients. Liver International. 2018

There are 854 studies on bromelain and counting:

1. Pavan, R., Jain, S., Shraddha, & Kumar, A. Properties and therapeutic application of bromelain: a review. Biotechnology Research International. 2012
2. Rathnavelu, V., Alitheen, N. B., Sohila, S., Kanagesan, S., & Ramesh, R. Potential role of bromelain in clinical and therapeutic applications. Biomedical reports. 2016

There are 204 studies and counting on artichoke leaf.

1. Miccadei S, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, Fraioli R, Mobarhan S, Maiani G. Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutr Cancer. 2008
2. Küçükgergin C, Aydin AF, Ozdemirler-Erata G, Mehmetçik G, Koçak-Toker N, Uysal M. Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet. Biol Trace Elem Res. 2010
3. Rangboo, V., et al. The effect of artichoke leaf extract on alanine aminotransferase and aspartate aminotransferase in the patients with nonalcoholic steatohepatitis. International Journal of Hepatology. 2016

There are 1,515 studies on dandelion root and counting.

1. Choi, U. K., et al. Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits. International Journal of Molecular Sciences. 2010
2. Domitrović, R., et al. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. Journal of Ethnopharmacology. 2010

There are 8,896 studies on turmeric and counting.

1. Farzaei, M. H., et al. Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients. 2018
2. Kunnumakkara, A. B., et al. Curcumin, the golden nutraceutical: multi targeting for multiple chronic diseases. British Journal of Pharmacology. 2017
3. Rahmani, S., et al. Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytotherapy Research. 2016

There are 1,038 studies on chicory root and counting.

1. Rizvi, W., Fayazuddin, M., Shariq, S., Singh, O., Moin, S., Akhtar, K., & Kumar, A. Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity. Ancient Science of Life. 2014
2. Ziamajidi, N., Khaghani, S., Hassanzadeh, G., Vardasbi, S., Ahmadian, S., Nowrouzi, A., ... & Abdirad, A. Amelioration by chicory seed extract of diabetes-and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1. ScienceDirect. 2013

There are 990 studies on yarrow and counting.

1. Ali, S. I., et al. Pharmacological and therapeutic potential of yarrow (Achillea millefolium L.). Journal of Pharmacognosy and Phytotherapy Pharmacognosy. 2017
2. Benedek, B., & Kopp, B. Achillea millefolium L. sl revisited: recent findings confirm the traditional use. Wiener Medizinische Wochenschrift. 2007
3. Potrich, F. B., et al. Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system. Journal of Ethnopharmacology. 2010

There are 5,488 studies on alpha lipoic acid and counting.

1. Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998
2. Rochette, L., et al. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. Canadian Journal of Physiology and Pharmacology. 2013
3. Arafat, A. M., et al. Clinical effects of oral antioxidative supplementation with alpha-lipoic acid in type 2 diabetic patients. Endocrine. 2017

There are 1,111 studies on ginger root and counting.

1. Mashhadi, N. S., et al. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. International Journal of Preventive Medicine. 2013
2. Sahebkar, A. Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World Journal of Gastroenterology. 2011
3. Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz SA. Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Hepat Mon. 2016

There are 1,370 studies on celery seed and counting.

1. Kooti W, Daraei N. A Review of the Antioxidant Activity of Celery (Apium graveolens L). J Evid Based Complementary Altern Med. 2017
2. Powanda MC, Rainsford KD. A toxicological investigation of a celery seed extract having anti-inflammatory activity. Inflammopharmacology. 2011

There are 6,140 studies on alfalfa and counting.

1. Bora, K. S., & Sharma, A. Phytochemical and pharmacological potential of Medicago sativa: A review. Pharmaceutical biology. 2011
2. Amraie, E., et al. The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats. Interventional Medicine and Applied Science. 2015

There are 449 studies on burdock root and counting.

1. Chan, Y. S., et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011
2. Lin, S. C., et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of Biomedical Science. 2002

There are 1,711 studies on bilberry fruit and counting.

1. Bao, L., et al. Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice. Journal of Agricultural and Food Chemistry. 2008
2. Takikawa, M., et al. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. The Journal of Nutrition. 2010

There are 259 studies on chanca piedra and counting.

1. Marques, F. Z., Mackay, C. R., & Kaye, D. M. Beyond gut feelings: how the gut microbiota regulates blood pressure. Nature Reviews Cardiology. 2018
2. Wang, B. E. Treatment of chronic liver diseases with traditional Chinese medicine. Journal of Gastroenterology and Hepatology. 2000
3. Pramyothin, P., Ngamtin, C., Poungshompoo, S., & Chaichantipyuth, C. Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies. Journal of Ethnopharmacology. 2007

There are 674 studies on elderberry and counting.

1. Hawkins, J., Baker, C., Cherry, L., & Dunne, E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary Therapies in Medicine. 2019

There are 24,245 studies on zinc and counting.

1. Zhong, W., Wei, X., Hao, L., Lin, T. D., Yue, R., Sun, X., ... & Zhou, Z. Zinc deficiency activates S1P3 -mediated hepatic stellate cell activation via the S1P3 /S1P lyase/SREBP1 positive feedback loop. Hepatology. 2020
2. Barbara M, Mindikoglu AL. The role of zinc in the prevention and treatment of nonalcoholic fatty liver disease. Metabol Open. 2021
3. Grüngreiff, K., & Reinhold, D. Zinc and the liver. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals (pp. 523-529). Academic Press. 2018

There are 5,930 studies on grape seed and counting.

1. Bak, M. J., et al. Grape seed proanthocyanidin extract ameliorates nonalcoholic fatty liver disease through regulation of lipid metabolism, oxidative stress and inflammatory cytokines. Journal of Functional Foods. 2016
2. Nassiri‐Asl, M., & Hosseinzadeh, H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive constituents: an update. Phytotherapy Research. 2016
3. Khoo, H. E., et al. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & Nutrition Research. 2017

There are 4,221 studies on beet root and counting.

1. Vulić, J. J., Čanadanović-Brunet, J. M., Ćetković, G. S., Tumbas, V. T., Djilas, S. M., Četojević-Simin, D. D., & Čanadanović, V. M. Antioxidant and cell growth activities of beet root pomace extracts. Journal of Functional Foods. 2012
2. Clifford, T., Howatson, G., West, D. J., & Stevenson, E. J. The potential benefits of red beetroot supplementation in health and disease. Nutrients. 2015
3. Ninfali, P., & Angelino, D. Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia. 2013

There are 6,840 studies on milk thistle seed extract and counting.

1. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010
2. Surai PF. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants (Basel). 2015
3. Ferenci P. Silymarin in the treatment of liver diseases: What is the clinical evidence? Clin Liver Dis (Hoboken). 2016

There are 4,353 studies on blueberry and counting.

1. Travica, N., et al. The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials. Brain, Behavior, and Immunity. 2020
2. Norberto, S., et al. Blueberry anthocyanins in health promotion: A metabolic overview. Journal of Functional Foods. 2013

There are 48,792 studies on glutathione and counting.

1. Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., ... & Nakajima, A. Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology. 2017
2. Sacco, R., Eggenhoffner, R., & Giacomelli, L. Glutathione in the treatment of liver diseases: insights from clinical practice. Minerva gastroenterologica e dietologica. 2016

There are 548 studies on TUDCA and counting.

1. Elia, A. E., Lalli, S., Monsurrò, M. R., Sagnelli, A., Taiello, A. C., Reggiori, B., ... & Albanese, A. Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis. European journal of neurology. 2016
2. Mueller, M., Castro, R. E., Thorell, A., Marschall, H. U., Auer, N., Herac, M., ... & Trauner, M. Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients. Liver International. 2018

There are 854 studies on bromelain and counting:

1. Pavan, R., Jain, S., Shraddha, & Kumar, A. Properties and therapeutic application of bromelain: a review. Biotechnology Research International. 2012
2. Rathnavelu, V., Alitheen, N. B., Sohila, S., Kanagesan, S., & Ramesh, R. Potential role of bromelain in clinical and therapeutic applications. Biomedical reports. 2016

There are 204 studies and counting on artichoke leaf.

1. Miccadei S, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, Fraioli R, Mobarhan S, Maiani G. Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutr Cancer. 2008
2. Küçükgergin C, Aydin AF, Ozdemirler-Erata G, Mehmetçik G, Koçak-Toker N, Uysal M. Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet. Biol Trace Elem Res. 2010
3. Rangboo, V., et al. The effect of artichoke leaf extract on alanine aminotransferase and aspartate aminotransferase in the patients with nonalcoholic steatohepatitis. International Journal of Hepatology. 2016

There are 1,515 studies on dandelion root and counting.

1. Choi, U. K., et al. Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits. International Journal of Molecular Sciences. 2010
2. Domitrović, R., et al. Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. Journal of Ethnopharmacology. 2010

There are 8,896 studies on turmeric and counting.

1. Farzaei, M. H., et al. Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients. 2018
2. Kunnumakkara, A. B., et al. Curcumin, the golden nutraceutical: multi targeting for multiple chronic diseases. British Journal of Pharmacology. 2017
3. Rahmani, S., et al. Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytotherapy Research. 2016

There are 1,038 studies on chicory root and counting.

1. Rizvi, W., Fayazuddin, M., Shariq, S., Singh, O., Moin, S., Akhtar, K., & Kumar, A. Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity. Ancient Science of Life. 2014
2. Ziamajidi, N., Khaghani, S., Hassanzadeh, G., Vardasbi, S., Ahmadian, S., Nowrouzi, A., ... & Abdirad, A. Amelioration by chicory seed extract of diabetes-and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1. ScienceDirect. 2013

There are 990 studies on yarrow and counting.

1. Ali, S. I., et al. Pharmacological and therapeutic potential of yarrow (Achillea millefolium L.). Journal of Pharmacognosy and Phytotherapy Pharmacognosy. 2017
2. Benedek, B., & Kopp, B. Achillea millefolium L. sl revisited: recent findings confirm the traditional use. Wiener Medizinische Wochenschrift. 2007
3. Potrich, F. B., et al. Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system. Journal of Ethnopharmacology. 2010

There are 5,488 studies on alpha lipoic acid and counting.

1. Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998
2. Rochette, L., et al. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. Canadian Journal of Physiology and Pharmacology. 2013
3. Arafat, A. M., et al. Clinical effects of oral antioxidative supplementation with alpha-lipoic acid in type 2 diabetic patients. Endocrine. 2017

There are 1,111 studies on ginger root and counting.

1. Mashhadi, N. S., et al. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. International Journal of Preventive Medicine. 2013
2. Sahebkar, A. Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World Journal of Gastroenterology. 2011
3. Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz SA. Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Hepat Mon. 2016

There are 1,370 studies on celery seed and counting.

1. Kooti W, Daraei N. A Review of the Antioxidant Activity of Celery (Apium graveolens L). J Evid Based Complementary Altern Med. 2017
2. Powanda MC, Rainsford KD. A toxicological investigation of a celery seed extract having anti-inflammatory activity. Inflammopharmacology. 2011

There are 6,140 studies on alfalfa and counting.

1. Bora, K. S., & Sharma, A. Phytochemical and pharmacological potential of Medicago sativa: A review. Pharmaceutical biology. 2011
2. Amraie, E., et al. The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats. Interventional Medicine and Applied Science. 2015

There are 449 studies on burdock root and counting.

1. Chan, Y. S., et al. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011
2. Lin, S. C., et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of Biomedical Science. 2002

There are 1,711 studies on bilberry fruit and counting.

1. Bao, L., et al. Protective effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced liver damage in mice. Journal of Agricultural and Food Chemistry. 2008
2. Takikawa, M., et al. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. The Journal of Nutrition. 2010

There are 259 studies on chanca piedra and counting.

1. Marques, F. Z., Mackay, C. R., & Kaye, D. M. Beyond gut feelings: how the gut microbiota regulates blood pressure. Nature Reviews Cardiology. 2018
2. Wang, B. E. Treatment of chronic liver diseases with traditional Chinese medicine. Journal of Gastroenterology and Hepatology. 2000
3. Pramyothin, P., Ngamtin, C., Poungshompoo, S., & Chaichantipyuth, C. Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies. Journal of Ethnopharmacology. 2007